Best has been ruled out of action since September after having surgery on his hip but could be set for action alongside scrum half Ryan Powell who is also among the replacements after breaking his foot.
Promising young flanker James Collins will lead the side as the two top sides in the Northern Conference in the Guinness A League battle it out.
Warriors Academy boss Andrew Stanley has named a strong side that includes Tongan wing Aisea Havili – who score a hat-trick in his last Guinness A League outing – Mark Tucker, Tim Collier and Shane Drahm.
Debenture and Season Ticket holders gain free admittance to the game. Adult tickets are £3 on the gate and juniors are free.
Warriors v Northampton Wanderers
15 Tom Wheatcroft
14 Uche Oduoza
13 Mark Tucker
12 Greg King
11 Aisea Havili
10 Shane Drahm
9 Nick Runciman
1 Jack Guilding
2 Jordan Page
3 Callum Black
4 Tim Collier
5 Matt Cox
6 Jake Abbott
7 James Collins (Captain)
8 Paula Havea
Replacements from:
Scott Wright, Liam Mullan, Jake Abbott, Ryan Powell, Joe Carlisle, Lee Best, Charley Thomas, Alex Grove
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